IngredientsExample
What Is PDRN?
Salmon DNA has become one of the most talked-about ingredients in Korean skincare. Here is where it came from, what it has been studied for, and where the evidence stops.
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- Art of Radiance Editorial
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- 2 min read
In this article
PDRN — polydeoxyribonucleotide — is a mixture of DNA fragments, most commonly extracted from salmon. It has a clinical history in wound care and regenerative medicine, particularly as an injectable, and has recently become a headline ingredient in Korean serums and ampoules.
The clinical background
In clinical settings, PDRN has been studied for supporting tissue repair through activation of adenosine A2A receptors, which are involved in reducing inflammation and encouraging new blood vessel formation. Trials in wound healing and certain skin conditions — mostly with injectable or medical-grade formulations — have shown encouraging results.
From clinic to cosmetic
The leap from injection to serum is a large one. DNA fragments are relatively large, water-soluble molecules; how much penetrates intact stratum corneum is uncertain. The hydrating, conditioning effects users describe are plausible and consistent with the formulations these products use. Regenerative effects of the kind seen in clinical studies should not be assumed.
Ingredient · Bioactive
PDRN
A DNA-derived compound, typically sourced from salmon, studied for tissue repair and now emerging in topical skincare.
From the library · Book 1
The Art of Radiance: The Secrets to Asian Style Skincare
Chapter 9 — Power Ingredients
A Comprehensive Guide to Asian Style Skincare and New Trends
References & further reading
- 01
Polydeoxyribonucleotide: a promising biological platform
Journal of Clinical Medicine, 2021
Art of Radiance distinguishes established evidence from emerging research and traditional practice. Read our science & sources approach.